Chromosomal locations of mcr-1 and bla CTX-M-15 in fluoroquinolone-resistant Escherichia coli ST410.

Authors: Falgenhauer, Linda and Waezsada, Said-Elias and Gwozdzinski, Konrad and Ghosh, Hiren and Doijad, Swapnil and Bunk, Boyke and Spröer, Cathrin and Imirzalioglu, Can and Seifert, Harald and Irrgang, Alexandra and Fischer, Jennie and Guerra, Beatriz and Käsbohrer, Annemarie and Overmann, Jörg and Goesmann, Alexander and Chakraborty, Trinad

To the Editor: Recently, Yi-Yun Liu et al. reported on the discovery of mcr-1, a plasmidborne resistance gene mediating resistance to colistin, in isolates obtained from humans and animals (1). Since the original publication, mcr-1 with or without the insertion element ISApl1 has been detected on plasmids of different incompatibility groups, including IncI2, IncHI2, and IncX4, and in many different countries (1–3). Because colistin is a last-resort parenteral antimicrobial drug, the transfer of mcr-1 by conjugation or through mobilizable plasmids raises concern about the emergence of pan-resistant Enterobacteriaceae.

Journal: Emerging infectious diseases
DOI: 10.3201/eid2209.160692
Year: 2016

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