This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Since the inception of next generation sequencing (NGS) more than a decade ago, short-read sequencing accuracy has seen only marginal improvement. Having achieved a level of precision thought to be…
As more researchers embrace the benefits of PacBio long-read sequencing technology, an expanding community of analysis tool developers has taken shape. Thanks to this growing excitement around PacBio capabilities there…
Cellular cartography has been just as important for biologists to navigate the complex topography of living systems as was the mapping of the earth’s landscapes for explorers hundreds of years…
Scientific breakthroughs are rarely achieved in isolation. They require collaboration, cutting-edge techniques, and a platform where scientists can come together to exchange knowledge and explore groundbreaking tools. And that’s exactly…
The new Revio long-read sequencing system, with its first customer shipment in March 2023, has changed the game in genomics. It enables researchers to access an entirely new echelon of…
If you have ever clicked around the PacBio website or attended a workshop or webinar discussing PacBio long-read sequencing technology, then you have probably seen or heard about SMRT (Single…
Delve deeper into the importance of capturing diversity with population-specific reference pangenomes. The movement towards the development of pangenomes is gaining steam, bringing the reality of truly personalized medicine closer….
The Revio system was built with the belief that game-changing technology should be simple to use. For a technology to be truly revolutionary it should deliver superior performance in conjunction…
Fresh off the special Nature issue last month on the first human pangenome reference (featured in a previous blog), the first regional human pangenome reference study, entitled A Pangenome Reference…
When developing effective personalized immunotherapies, such as cancer vaccines, a pivotal factor lies in uncovering tumor neoantigens that can serve as crucial therapeutic targets. Traditionally, neoantigen discovery heavily relied on…
Large-scale population sequencing programs have a number of important research goals and outcomes. These include: Generating a comprehensive catalogue of genetic variation to reflect the genetic diversity in a target…
This article explores sequencing coverage fundamentals. Uncover key concepts and discover how highly accurate long-read sequencing provides a comprehensive view of the genome, at any coverage level. What is sequencing…
In recent years, whole exome sequencing (WES) has become a popular method for identifying the genetic underpinnings of disease in both research and clinical settings. However, because an exome is…
Understanding the myriad of different cell types, states, and their functions is essential to understanding biology. Cell atlas projects and consortia aim to map different cell types in tissues, organs,…
With Earth Day almost here, it is important to remember that our planet is made up of countless interconnected parts, from vast oceans to the microscopic world of microbes. Despite…
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