Rapid transcriptional responses to serum exposure are associated with sensitivity and resistance to antibody-mediated complement killing in invasive Salmonella Typhimurium ST313

Authors: Ondari, Edna M and Klemm, Elizabeth J and Msefula, Chisomo L and El Ghany, Moataz Abd and Heath, Jennifer N and Pickard, Derek J and Barquist, Lars and Dougan, Gordon and Kingsley, Robert A and MacLennan, Calman A

Background: Salmonella Typhimurium ST313 exhibits signatures of adaptation to invasive human infection, including higher resistance to humoral immune responses than gastrointestinal isolates. Full resistance to antibody-mediated complement killing (serum resistance) among nontyphoidal Salmonellae is uncommon, but selection of highly resistant strains could compromise vaccine-induced antibody immunity. Here, we address the hypothesis that serum resistance is due to a distinct genotype or transcriptome response in S. Typhimurium ST313.

Journal: Wellcome open research
DOI: 10.12688/wellcomeopenres.15059.1
Year: 2019

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